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Ray, J. FISH can be utilized as a research tool to Hot Fulshear Texas pussy the origins of marker chromosomes. The phenotypic consequences of a marker chromosome derived from the short arm of chromosome 16 are described. A year-old woman underwent amniocentesis at 28 weeks gestation because of a prenatally diagnosed tetralogy of Fallot.

Follow-up ultrasounds also showed ventriculomegaly and cleft lip and palate. At birth the ultrasound findings were confirmed and dysmorphic features and cryptorchidism were noted.

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Although a newborn blood sample contained only normal cells, mosaicism was confirmed in 2 skin biopsies. FISH using whole-chromosome painting and alpha-satellite DNA probes showed that the marker chromosome had originated from chromosome At 15 months of age, this child is hypotonic, globally delayed and is gavage-fed.

His physical examination is ificant for microbrachycephaly, a round face, sparse scalp hair, ocular hypertelorism, exotropia, a flat, wide nasal bridge and tip, mild micrognathia, and tapered fingers with lymphedema of hands and feet.

Inguinal hernias have been repaired. His features are consistent with those described for patients trisomic for most or all of the short arm of chromosome Marker chromosomes derived from the short arm of chromosome 16 appear to Wife swapping in Hyampom CA phenotypic consequences.